The pursuit of longevity has evolved from merely adding years to life toward extending healthspan—the period of vitality, resilience, and purpose. Integrating the insights of Eric Topol, David Sinclair, and Peter Attia, a holistic roadmap emerges: Lifestyle+ habits like exercise, whole-food nutrition, restorative sleep, and meaningful social connection work synergistically with advanced biomedical technologies such as proteomic clocks, epigenetic reprogramming, and AI-driven precision medicine. Environmental exposures, socioeconomic factors, and mental well-being are equally crucial, framing longevity as a multidimensional endeavor. The fusion of low-tech discipline, high-tech monitoring, and high-touch human connection creates a practical, actionable, and equitable framework for living longer, healthier, and more meaningful lives.