Autism, gut health, and black seed oil intersect at the core of inflammation, immune regulation, and microbiome balance, offering a holistic framework for improving quality of life. While autism itself is not curable, addressing gut dysfunction through diet, microbiome support, psychobiotics, and carefully introduced black seed oil can reduce digestive issues, stabilize behavior, enhance sleep, and modulate immune responses. Grounded in evidence from pioneering works like Brain Maker, GAPS, and The Autoimmune Solution, a structured, phased approach empowers families to observe patterns, personalize interventions, and foster calm, resilient physiology. The greatest impact arises from combining nutritional strategies, microbiome optimization, immune support, and mindful caregiving within supportive, sustainable ecosystems that honor each child’s unique biology and potential.